Chong is well known for his stereotypical portrayals of hippie-era stoners. He is most widely known for his role as Anthony Stoner in the marijuana-themed Cheech & Chong comedy movies with Cheech Marin. He also played Leo Chingkwake in That '70s Show.
On September 4, 2014, Chong was announced as one of the celebrities participating on the 19th season of Dancing with the Stars. He paired with professional dancer Peta Murgatroyd. Despite being at the bottom of the leaderboard numerous times, Chong and Murgatroyd were able to make it to the night of the semi-finals but were eliminated at the end of that night. Chong is the oldest contestant to have made it to the semi-finals of the show.
He originally was supposed to be in Disney's The Lion King with Cheech Marin, voicing one of the hyenas, but one of them was changed to a female, voiced by Whoopi Goldberg.
On April 4, 2015, Chong was in Ann Arbor, Michigan, for the annual "Hash Bash" event which focuses on cannabis legalization. He was a guest speaker at this event, and took pictures with fans and signed autographs.