Slate wrote the script for a reboot of the Looney Tunes franchise for Warner Bros. She co-created and voiced Marcel, a talking shell with an Oobi eye and a pair of doll shoes, in Marcel the Shell with Shoes On.
Slate's first major role in a film was as Zoe, an antagonist, from Alvin and the Chipmunks: Chipwrecked. She starred in Obvious Child, which won her the Critics' Choice Movie Award for Best Actress in a Comedy.
- Jenny Slate was a guest star on the HBO show Hello Ladies which starred Nate Torrence.
- She appeared in the 2017 film Gifted with Octavia Spencer.
- She starred in House of Lies with Kristen Bell.
- She co-starred with Alan Tudyk in Alvin and the Chipmunks: Chipwrecked.
- She co-starred with Jason Bateman in The Longest Week.